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A 1992 report associated the use of anabolic steroids with tinea versicolor, a fungal skin disease sensitive to sun exposure. But a 1994 report found no association between steroid use and tinea versicolor and concluded "the reported relationship between steroid use and tinea versicolor is unlikely to be causal." "It's like, there's a thousand theories around this," said Dr. Michael O. Koppelman, a dermatologist at Columbia University in New York. "It may be that steroids are causing the skin problem, the fungus is causing the steroids, or the fungus is causing the steroid." Even so, Dr. Koppelman said there are "a plethora of factors" that lead to the development of acne and then an increase in skin problems, such as sun exposure. That's where a new drug developed by the drug companies might come in. It's a combination drug called natalizumab. It's used to treat patients with severe inflammatory acne. But in a study conducted at Dartmouth College last year, one group of patients received a four-week dose of natalizumab and another group received a placebo. The study results showed a significant reduction in acne. The Dartmouth study had more than 100 participants with very severe acne and nearly half had taken steroids for more than 10 years before that. The second group had never been on steroids, and they had a significantly lower number of inflammatory lesions. Dr. Efraim Levy, the director of the Yale School of Medicine, said that the study "is a really elegant way of doing this, in a controlled setting." "I have never seen anything like this before — a placebo, an active treatment, on a serious inflammatory outbreak such as this," Dr. Levy said. "I'm still amazed it hasn't been studied in more people." And because of his involvement at Dartmouth, Dr. Levy said it is "probably too late" to make sure that the new drug doesn't cause another outbreak — a complication of the drug — in acne patients. Another group of patients with persistent acne at Dartmouth also got natalizumab and were told they might have had a skin disorder called erythema nodosum. It is the same condition that leads to severe skin scarring caused by steroid use. The researchers at Dartmouth gave the volunteers who got natalizumab a "scalp tonic" along with a cream after the study to take for about a week, but after three weeks all of the participants in the group who received the placebo became less sensitive Similar articles:

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